Mechanism of Digeranylgeranylation of Rab Proteins

Geranylgeranylation of Rab proteins.

37 James, G. L., Goldstein, J. I,., Brown, M. S., Rawson, T. E., Somers, T. C., McDowell, R. S., Crowlcy, C. W., Lucas, B. K., Levinson, A. D. and Marsters, Jr., J. C. (1993) Science 260, 1937-1942 38 Cox, A. D., Garcia, A. M., Westwick, J. K., Kowalczyk, J. J., Lewis, M. D., Brenner, D. A. and Iler, C. J. (1994) J. Biol. Chem. 269, 19203-19206 39 Manne, V., Yan, N., Carlioni, J. M., Tuomari, A...

Flavors of Drosophila Rab Proteins

functional study of p0 proteins of two cereal yellow dwarf viruses (cydv-rpv and cydv-rps) and identification of their cellular partner

نقش سرکوبگری پروتئین p0 در دو پولروویروس کوتولگی زردی غلات cydv-rpv) و (cydv-rps، متفاوت در شدت بیماریزایی، مورد مطالعه قرار گرفت. نتایج نشان داد که هر دو پروتئین p0 p0cy-rpv) و (p0cy-rps قادر به سرکوب خاموشی آر ان ای ایجاد شده توسط ترادف های تراژن سنس و تکرار معکوس در n. benthamiana هستند. نشان داده شد که هر دو پروتئین p0 می توانند تخریب پروتئین argonaute-1 را تسهیل کنند. علاوه بر این، تمایل م...

Functions of Rab Proteins at Presynaptic Sites

Presynaptic neurotransmitter release is dominated by the synaptic vesicle (SV) cycle and entails the biogenesis, fusion, recycling, reformation or turnover of synaptic vesicles-a process involving bulk movement of membrane and proteins. As key mediators of membrane trafficking, small GTPases from the Rab family of proteins play critical roles in this process by acting as molecular switches that...

Thirty-one flavors of Drosophila rab proteins.

Rab proteins are small GTPases that play important roles in transport of vesicle cargo and recruitment, association of motor and other proteins with vesicles, and docking and fusion of vesicles at defined locations. In vertebrates, >75 Rab genes have been identified, some of which have been intensively studied for their roles in endosome and synaptic vesicle trafficking. Recent studies of the f...